|
KMID : 1038220140410010035
|
|
Archives of Plastic Surgery
2014 Volume.41 No. 1 p.35 ~ p.39
|
|
|
Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
|
|
Cho Moon-Kyun
An Je-Min
Kim Chul-Han
Kang Sang-Gue
|
|
|
Abstract
|
|
|
Background: Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.
Methods: Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.
Results: Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.
Conclusions: Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
|
|
|
KEYWORD
|
|
|
Skin, Diabetes mellitus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|